If one of the consumables generated by this effect is a heart, converting it with Apple of Sodom or Keeper will not cause the other consumable to disappear.Likewise, the other reward will not disappear if the troll bomb blows up. If one of the rewards is a troll bomb, picking up the other reward will not make the troll bomb disappear.
If Isaac directly interacts with one, the other disappears.
Upon completing a room, if a room clear reward would spawn, another different reward spawns next to it.